Be it Diabetic neuropathy, Herniated disc, Shingles, Tumor or Physical injuries, the causes of nerve pain are scary and so is the pain. The other causes include stress, vitamin deficiency, hormonal imbalance, amputated limb, stroke multiple sclerosis etc. The most common symptom being nerve pain. The reason for such pain is the neuronal messaging system that goes haywire due to an injury or disease and it sends pain signals to the brain. The pain in such conditions is different from the normal pain and the condition also depends on whether the nerves are affected in periphery or CNS, and which nerves are affected. In diabetic neuropathy the sensory nerves are most often affected, causing burning or numbness.
The pain is not what usual pain feels like, it is a numbing sensation with a burning feeling, the patients also observe a pin and needles kind of piercing pain that travels where ever the damaged nerve travels. These patients have a lot to bear as the pain is uncontrollable and normal pain killers do little to control it. The movement is hampered and so is normal living. To cure nerve pain, a much stronger analgesic is needed that works specifically to control such pain. the best available among such drugs is Lyrica.
Lyrica is a well-accepted drug for the treatment of neuropathic pain which generally affects arms, hands, fingers, legs, feet or toes. This medication is a highly potent pain reliever that effectively manages nerve pain in diabetic neuropathy, shingles, herpes zoster, fibromyalgia and spinal cord injury. It is a capsule dosage form that contains Pregabalin as its chief therapeutic ingredient. Lyrica manages pain by suppressing certain chemicals and diminishes the impulses in the brain which is accountable for sending pain signals.
Pregabalin belongs to the anticonvulsants category of drug. It is an analog of GABA (potent inhibitory neurotransmitter). The drug exerts beneficial effects by interacting with alpha2-delta site in the CNS. In addition, it modifies the calcium channel function by decreasing the release of certain calcium dependent neurotransmitters. Pregabalin augments the concentration of GABA by enhancing the availability of an enzyme called GAD. As a result, electric signals from the damaged nerves are suppressed and pain signals do not travel to the brain.
Lyrica is available in dosing strengths of 75mg, 150mg, and 200mg. The dose is best defined by the doctor. While treating diabetic neuropathy, the therapy is usually initiated with 50 mg orally taken 3 times a day which can be further augmented to 100 mg orally taken 3 times a day within one weeks time, keeping in mind the efficacy and tolerability. While treating Post herpetic Neuralgia, the initial dose is 75 mg orally, taken 2 times a day or 50 mg orally 3 times a day, the dose can be further increased to 100 mg orally thrice a day after one week based on efficacy and tolerability.
The most commonly occurring side effects that may bother a few of the users are a drowsiness, confusion, edema, headache, dizziness infection, blurred vision, constipation, fatigue, speech disturbance and increased appetite.
Preventive measures while using Lyrica:
- The use of alcohol or any other recreational drugs with this medication can increase the side effects.
- The elderly are more prone to the side effects of this medicine. They should take it under proper medical guidance.
- Keep a safe distance from driving or doing possibly unsafe tasks as the use of this medication may induce dizziness and drowsiness effects.
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